Inflammaging markers characteristic of advanced age show similar levels with frailty and dependency

Regular Fat and Reduced Fat Dairy Products Show Similar Associations with Markers of Adolescent Cardiometabolic Health.

Reduced fat dairy products are generally recommended for adults and children over the age of two years. However, emerging evidence suggests that dairy fat may not have detrimental health effects. We aimed to investigate prospective associations between consumption of regular versus reduced fat dairy products and cardiometabolic risk factors from early to late adolescence. In the West Australian...

Time-to-death patterns in markers of age and dependency

We aim to determine the extent to which variables commonly used to describe health, well-being, and disability in old-age vary primarily as a function of years lived (age), years left, or as a function of both. We analyze data from the US Health and Retirement Study to estimate chronological age and time-to-death patterns in 60 such variables. We describe results for individuals with 15 or fewe...

Biological markers of frailty

Understanding how we age: insights into inflammaging

Inflammaging is characterized by the upregulation of the inflammatory response that occurs with advancing age; its roots are strongly embedded in evolutionary theory.Inflammaging is believed to be a consequence of a remodelling of the innate and acquired immune system, resulting in chronic inflammatory cytokine production.Complex interrelated genetic, environmental and age-related factors deter...

Age-related frailty and its association with biological markers of ageing

BACKGROUND The relationship between age-related frailty and the underlying processes that drive changes in health is currently unclear. Considered individually, most blood biomarkers show only weak relationships with frailty and ageing. Here, we examined whether a biomarker-based frailty index (FI-B) allowed examination of their collective effect in predicting mortality compared with individual...